Ospreys Captain Justin Tipuric will lead his country against Georgia at Parc Y Scarlets this weekend.
He's join by regional teammates Sam Parry and Nicky Smith who provide the cover off the bench alongside Rhys Webb who makes his return to the matchday 23.
“Saturday is a huge opportunity for the players and for us as a squad looking ahead to the future and to RWC 2023,” said Wales head coach Wayne Pivac.
“As we have said all along, the Autumn Nations Cup is a great platform for us to give opportunities to players, to build depth and experience.
“It’s a great honour for the new caps and the players making their first starts, they have trained well and deserve this opportunity to represent their country.”
WALES TEAM TO PLAY GEORGIA (Saturday November 21 KO17.15):
15. Liam Williams (Scarlets) (65 Caps)
14. Johnny McNicholl (Scarlets) (4 Caps)
13. Nick Tompkins (Dragons) (6 Caps)
12. Johnny Williams (Scarlets) (*Uncapped)
11. Louis Rees-Zammit (Gloucester) (1 Cap)
10. Callum Sheedy (Bristol Bears) (1 Cap)
9. Kieran Hardy (Scarlets) (*Uncapped)
1. Wyn Jones (Scarlets) (27 Caps)
2. Elliot Dee (Dragons) (30 Caps)
3. Samson Lee (Scarlets) (43 Caps)
4. Jake Ball (Scarlets) (47 Caps)
5. Seb Davies (Cardiff Blues) (8 Caps)
6. James Botham (Cardiff Blues) (*Uncapped)
7. Justin Tipuric (Ospreys) (78 Caps) (CAPT)
8. Aaron Wainwright (Dragons) (24 Caps)
16. Sam Parry (Ospreys) (2 Caps)
17. Nicky Smith (Ospreys) (36 Caps)
18. Leon Brown (Dragons) (10 Caps)
19. Cory Hill (Cardiff Blues) (27 Caps)
20. James Davies (Scarlets) (9 Caps)
21. Rhys Webb (Ospreys) (34 Caps)
22. Ioan Lloyd (Bristol Bears) (*Uncapped)
23. Jonah Holmes (Dragons) (3 Caps)