Nikki Walker and Ben Lewis will make their returns from long-term injury when the Ospreys face Leeds Carnegie at the Liberty Stadium on Saturday (KO 2.30pm).
Walker has been out of action since tearing a hamstring in the Heineken Cup win against Benetton Treviso at the Liberty Stadium in December, while Ben Lewis missed the whole of the 2008/09 season after undergoing ACL reconstruction surgery.
Saturdays fixture will also provide Ospreys supporters with their first opportunity to see summer signings Jerry Collins, Ross Davies, Barry Davies, Liam Davies and Tom Isaacs in the new-look black and gold Ospreys shirt.
The squad for Saturdays match has been confirmed as:
Tickets for the game are available to buy at the Liberty Stadium Ticket Office, online at www.ospreysrugby.com or via the Ticket Hotline on 08700 400 004