The Ospreys suffered a second successive defeat of the season against Munster at Thomond Park.
Sean Holley's men fought harder than the 43-9 defeat in the Heineken Cup quarter-final on the same venue last month but it still wasn't good enough. Paul O'Connell led the Magners League champions to a bonus-point victory over the Welsh region.
Lions flanker David Wallace touched down twice - in either half - along with Denis Leamy and Paul Warwick before replacement Anthony Horgan sealed maximum points on his final appearance. James Hook scored all the points for the Ospreys.