Will Jones and Will Griffiths will again represent the Ospreys at the World Rugby U20 Championship, named to start against England on Sunday, with Reuben Morgan-Williams on the bench.
Wales have made four changes, one of which is positional, for the must-win game at Avchala Stadium, Tbilisi (5.30pm BST).
Following their slender defeat to Australia in the opening match, Jason Strange's side must win to keep alive their hopes of reaching the semi-finals in Georgia.
With such a short turnaround between matches, Strange has been forced to make a handful of changes with Jared Rosser starting on the wing and Owen Lane moving to centre, in the place of injured Cameron Lewis.
Up front Sean Moore and Aled Ward replace Callum Bradbury and James Botham respectively, who drop to the bench.
While Wales U20 lost to the auld enemy during the Six Nations, they triumphed in the previous two and Strange has been enthused by elements of their performance against Australia.
He said: "We've had a couple of minor injuries so we've had to rotate players a little bit. The players coming in are fresh and enthusiastic and we've moved Owen Lane into the centre, who will offer something different.
"We certainly won't be overawed by it. In the U20s we have beaten England twice in the last three and we know what they will bring.
"That's a big driving lineout and they'll use their No 8 to gain a lot of momentum. It's about looking at their strengths but also understanding what our strengths are and bringing our best game on Sunday.
"We're confident, it was a good performance against Australia, we just need to be a little more clinical with our opportunities and hopefully we will do well."
There is one further change on the replacements bench with Stef Thomas covering tight-head after Scott Jenkins was ruled out of the tournament with an ankle injury after coming on as a late second half replacement against Australia.
Harri Dobbs has subsequently been called up to the extended Wales squad and has already arrived in Georgia.
Wales U20 to face England U20
15 Will Talbot-Davies (Newport Gwent Dragons)
14 Jared Rosser (Newport Gwent Dragons/Wales Sevens)
13 Ioan Nicholas (Scarlets)
12 Owen Lane (Cardiff Blues)
11 Ryan Conbeer (Scarlets)
10 Arwel Robson (Newport Gwent Dragons)
9 Dane Blacker (Cardiff Blues)
1 Rhys Carre (Cardiff Blues)
2 Ellis Shipp (Newport Gwent Dragons)
3 Kieron Assiratti (Cardiff Blues)
4 Will Griffiths (Ospreys)
5 Sean Moore (Pontypridd)
6 Shane Lewis-Hughes (Cardiff Blues)
7 Will Jones (c) (Ospreys)
8 Aled Ward (Cardiff Blues)
16 Owen Hughes (Newport Gwent Dragons)
17 Tom Mably (Cardiff Blues)
18 Stef Thomas (Scarlets)
19 Callum Bradbury (Cardiff Blues)
20 James Botham (Cardiff Blues)
21 Reuben Morgan-Williams (Ospreys)
22 Ben Jones (Cardiff Blues)
23 Joe Goodchild (Newport Gwent Dragons)