Adam Beard will make his Lions debut this Wednesday evening when the tourists take on Cell C Sharks at Emirates Airline Park (kick off 6pm BST).
Tom Curry (Sale Sharks, England)and Josh Navidi (Cardiff Rugby, Wales) will also make their debuts for the side out in South Africa.
Ireland lock, Iain Henderson (Ulster Rugby, Ireland), will captain the Lions for the first time, while Tour Captain, Conor Murray (Munster Rugby, Ireland), is named amongst the replacements.
The game, which will be shown live and exclusively on Sky Sports, is the second of eight Tour matches in the 2021 Castle Lager Lions Series which culminates with three Tests against World Champions, the Springboks.
“It’s a quick turnaround from Saturday, but we’ll be ready to go by Wednesday night,” said Lions Head Coach Warren Gatland.
“I’m pleased we managed to come through the weekend’s game unscathed, and the boys have rested and recovered well. We feel like we’re slowly building, but, as ever, there’s still room for improvement in all facets of our game.
“Wednesday night is another chance for us to have a look at a few more combinations. I’m looking forward to seeing how the back row goes; it’s an exciting mixture and one that we hope will offer something a bit different.
“We expect another physical test against a side who are known for their power play and ambition.
“My congratulations to Tom, Josh and Adam ahead of their first starts in a Lions jersey.”
CELL C SHARKS v THE BRITISH & IRISH LIONS
Wednesday 7 July 2021
Emirates Airline Park, Johannesburg
Kick-off: 6pm (BST)
15. Liam Williams (Scarlets, Wales) #833
14. Anthony Watson (Bath Rugby, England) #816
13. Elliot Daly (Saracens, England) #822
12. Bundee Aki (Connacht Rugby, Ireland) #837
11. Duhan van der Merwe (Worcester Warriors, Scotland) #841
10. Dan Biggar (Northampton Saints, Wales) #821
9. Gareth Davies (Scarlets, Wales) #850
1. Mako Vunipola (Saracens, England) #787
2. Luke Cowan-Dickie (Exeter Chiefs, England) #851
3. Zander Fagerson (Glasgow Warriors, Scotland) #848
4. Iain Henderson – Captain (Ulster Rugby, Ireland) #808
5. Adam Beard (Ospreys, Wales)
6. Josh Navidi (Cardiff Rugby, Wales)
7. Tom Curry (Sale Sharks, England)
8. Sam Simmonds (Exeter Chiefs, England) #849
16. Ken Owens (Scarlets, Wales) #829
17. Rory Sutherland (Worcester Warriors, Scotland) #840
18. Tadhg Furlong (Leinster Rugby, Ireland) #818
19. Tadhg Beirne (Munster Rugby, Ireland) #838
20. Jack Conan (Leinster Rugby, Ireland) #839
21. Conor Murray (Munster Rugby, Ireland) #790
22. Stuart Hogg (Exeter Chiefs, Scotland) #783
23. Chris Harris (Gloucester Rugby, Scotland) #844