| Date | Time | Comp | Home |
| Away | Venue | TV/Att | Rept |
|---|
| August 2010 |
| Tue 10 Aug | 19:00 | F | Ospreys Regional XV | v | Ospreys | Talbot Athletic Ground |
| More |
| Sat 14 Aug | 15:00 | F | Leeds Carnegie | v | Ospreys | Headingley Carnegie |
| More |
| Sat 21 Aug | 14:30 | F | Ospreys | v | Gloucester Rugby | The Liberty Stadium |
| More |
| September 2010 |
| 3/4/5 Sep |
| ML | Ulster Rugby | v | Ospreys | Ravenhill |
| More |
| 10/11/12 Sep |
| ML | Ospreys | v | Benetton Treviso | The Liberty Stadium |
| More |
| 17/18/19 Sep |
| ML | Munster | v | Ospreys | TBA |
| More |
| 24/25/26 Sep |
| ML | Ospreys | v | Aironi Rugby | The Liberty Stadium |
| More |
| October 2010 |
| 1/2/3 Oct |
| ML | Scarlets | v | Ospreys | Parc y Scarlets |
| More |
| Sat 9 Oct | 14:35 | HC-P3 | Toulon | v | Ospreys | Stade Mayol |
| More |
| Fri 15 Oct | 20:00 | HC-P3 | Ospreys | v | London Irish | The Liberty Stadium |
| More |
| 22/23/24 Oct |
| ML | Glasgow Warriors | v | Ospreys | Firhill |
| More |
| 29/30/31 Oct |
| ML | Ospreys | v | Newport Gwent Dragons | The Liberty Stadium |
| More |
| November 2010 |
| 5/6/7 Nov |
| LVC-P1,P4 | Newcastle Falcons | v | Ospreys | Kingston Park |
| More |
| 12/13/14 Nov |
| LVC-P1,P4 | Ospreys | v | Leicester Tigers | TBA |
| More |
| 19/20/21 Nov |
| ML | Connacht Rugby | v | Ospreys | Sportsground |
| More |
| 26/27/28 Nov |
| ML | Ospreys | v | Leinster | The Liberty Stadium |
| More |
| December 2010 |
| 3/4/5 Dec |
| ML | Ospreys | v | Edinburgh | The Liberty Stadium |
| More |
| Sun 12 Dec | 13:00 | HC-P3 | Munster | v | Ospreys | Thomond Park |
| More |
| Sat 18 Dec | 15:45 | HC-P3 | Ospreys | v | Munster | The Liberty Stadium |
| More |
| 24/25/26 Dec |
| ML | Ospreys | v | Scarlets | The Liberty Stadium |
| More |
| 31 Dec, |
| ML | Cardiff Blues | v | Ospreys | Cardiff City Stadium |
| More |
| January 2011 |
| 7/8/9 Jan |
| ML | Leinster | v | Ospreys | Royal Dublin Society |
| More |
| 14/15/16 Jan |
| HC-P3 | London Irish | v | Ospreys | Madejski Stadium |
| More |
| 21/22/23 Jan |
| HC-P3 | Ospreys | v | Toulon | The Liberty Stadium |
| More |
| 28/29/30 Jan |
| LVC-P1,P4 | Cardiff Blues | v | Ospreys | Cardiff City Stadium |
| More |
| February 2011 |
| 4/5/6 Feb |
| LVC-P1,P4 | Ospreys | v | London Wasps | TBA |
| More |
| 11/12/13 Feb |
| ML | Ospreys | v | Ulster Rugby | The Liberty Stadium |
| More |
| 18/19/20 Feb |
| ML | Benetton Treviso | v | Ospreys | Stadio Comunale di Monigo |
| More |
| 25/26/27 Feb |
| ML | Ospreys | v | Connacht Rugby | The Liberty Stadium |
| More |
| March 2011 |
| 4/5/6 Mar |
| ML | Ospreys | v | Glasgow Warriors | The Liberty Stadium |
| More |
| 25/26/27 Mar |
| ML | Edinburgh | v | Ospreys | Murrayfield |
| More |
| April 2011 |
| 1/2/3 Apr |
| ML | Ospreys | v | Cardiff Blues | The Liberty Stadium |
| More |
| 15/16/17 Apr |
| ML | Newport Gwent Dragons | v | Ospreys | Rodney Parade |
| More |
| 22/23/24 Apr |
| ML | Ospreys | v | Munster | The Liberty Stadium |
| More |
| May 2011 |
| 6/7/8 May |
| ML | Aironi Rugby | v | Ospreys | Stadio Luigi Zaffanella |
| More |
|
